Search results for "in vitro exercise"

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Branched-Chain Amino Acid Deprivation Decreases Lipid Oxidation and Lipogenesis in C2C12 Myotubes

2022

Impaired lipid metabolism is a common risk factor underlying several metabolic diseases such as metabolic syndrome and type 2 diabetes. Branched-chain amino acids (BCAAs) that include valine, leucine and isoleucine have been proven to share a role in lipid metabolism and hence in maintaining metabolic health. We have previously introduced a hypothesis suggesting that BCAA degradation mechanistically connects to lipid oxidation and storage in skeletal muscle. To test our hypothesis, the present study examined the effects of BCAA deprivation and supplementation on lipid oxidation, lipogenesis and lipid droplet characteristics in murine C2C12 myotubes. In addition, the role of myotube contract…

metabolic healthEXERCISEaminohapotMETABOLISMDEHYDROGENASE COMPLEXSUPPLEMENTATIONrasva-aineenvaihduntain vitro exerciseALPHAACTIVATIONMICEaineenvaihduntahäiriötCONTRACTIONelectrical pulse stimulationSKELETAL-MUSCLE1182 Biochemistry cell and molecular biologylipids (amino acids peptides and proteins)skeletal muscleaikuistyypin diabetesOBESElihassolutprotein supplementationnuclear magnetic resonance spectroscopy

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